Jose Mourinho is expected to shake things up and name virtually an entirely different Tottenham XI to the one that beat Manchester City 2-0 on Saturday. Spurs are looking to make it three wins from four in the Europa League group stages, when Bulgarian side Ludogorets travel to north London in Group J.
Tottenham currently sit top of the pile but remain level on six points with fellow contenders Antwerp and LASK.
Therefore, Mourinho will want to ensure his side capitalise on their home advantage to put one foot in the knockout stages.
Tottenham will be without Toby Alderweireld after Mourinho revealed the Belgian will miss up to four weeks of action.
The centre-back was excellent to keep City at bay last weekend but limped off with a groin problem.
However, this could be a good chance for him to build up some rhythm with Ben Davies set to start at left-back.
In midfield, Moussa Sissoko is the only star to keep his place from the weekend in addition to Dier.
He should partner Harry Winks at the base of midfield with Giovani Lo Celso in front, as the No 10.
Lucas Moura should come back in on the right side of attack, with Gareth Bale on the opposite flank.
Brazilian striker Carlos Vinicius will lead the line as Harry Kane and Son Heung-min look set to earn some much-needed rest.
Erik Lamela misses out through injury while simply to Rodon, Gedson Fernandes and Paulo Gazzaniga are not registered.
Mourinho can name 12 substitutes for the match and will be able to bring five of those onto the field.
Expected Tottenham XI vs Ludogorets (4-2-3-1): Hart; Doherty, Sanchez, Dier, Davies; Sissoko, Winks; Bale, Lo Celso, Lucas; Vinicius.