The match, orginally scheduled for the opening weekend of the season before being postponed, will see Edinson Cavani return from suspension after a three-match ban.
With a double-header to come against Liverpool, first in the league and then the FA Cup, Ole Gunnar Solskjaer could turn to Cavani’s fresh legs.
Further back, Eric Bailly will be assessed ahead of kick-off after coming off against Watford. There are also question marks over Victor Lindelof, in which case Alex Tuanzebe should deputise if the pair are not fit.
Scott McTominay played the full 90 minutes against Watford so could be rested, meaning Nemanja Matic would come in.
David de Gea will come back in between the sticks, with Marcus Rashford and Bruno Fernandes also nailed on.
Predicted Manchester United XI (4-3-3): De Gea; Wan-Bissaka, Lindelof, Maguire, Shaw; McTominay, Pogba, Fred, Fernandes; Rashford, Martial
Injury list: Phil Jones (knee), Marcos Rojo (calf), Facundo Pellistri (Covid-19)
Doubts: Eric Bailly (neck), Victor Lindelof (back), Paul Pogba (knock), Luke Shaw (knock)